In-vivo mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Brainhttps://doi.org/10.26165/JUELICH-DATA/HDVEEFKaulen, NicolasRajkumar, RavichandranRégio Brambilla, ClaudiaMauler, JörgRamkiran, ShuktiOrth, LindaSbaihat, HasanLang, MarkusChristina, WyssRota Kops, ElenaScheins, JürgenNeumaier, BerndErmert, JohannesHerzog, HansLangen, Karl-JosefChristoph LercheShah, N.JonVeselinović, TanjaNeuner, IreneJülich DATA2021-12-132022-03-15T12:28:39ZThis Dataset holds the results of the manuscript entitled "mGluR₅ and GABA_A Receptor Specific Parametric PET Atlas Construction - PET/MR Data Processing Pipeline, Validation and Application". In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BP_ND), and total distribution volume (V_T) based on simultaneously acquired bolus-infusion positron emission tomography (PET) and magnetic resonance imaging (MR) data. The pipeline was applied to [¹¹C]ABP688-PET/MR (13 healthy male non- smokers, 26.6 ± 7.0 years) and [¹¹C]Flumazenil-PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as V_T and BP_ND atlases of mGluR₅ and GABA_A, were generated from these data. An evaluation of PET-to-PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [¹⁵O]H₂O-template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposedpipeline is a viable tool for the construction of standardized PET data distributions. The maps were released to aid further research, by providing healthy in vivo references for the two mentioned neuroreceptor systems which may be used to assess associations with psychiatric and neurologic diseases. In addition, templates of normalized activity concentration distribution were released which were shown to benefit direct PET to PET registration for tracer-specific data.Medicine, Health and Life SciencesmGluR5, GABAA, PET/MRKaulen, N., Rajkumar, R., Régio Brambilla, C., Mauler, J., Ramkiran, S., Orth, L., Sbaihat, H., Lang, M., Wyss, C., Rota Kops, E., Scheins, J., Neumaier, B., Ermert, J., Herzog, H., Langen, K.-J., Lerche, C., Shah, N. J., Veselinović, T., & Neuner, I. (2022). mGluR5 and GABAA receptor-specific parametric PET atlas construction—PET/MR data processing pipeline, validation, and application. Human Brain Mapping, 1– 16. https://doi.org/10.1002/hbm.25778, doi, https://doi.org/10.1002/hbm.25778, https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.25778Kaulen, Nicolas2021-09-29CC0CC0 Waiver1 Forschungszentrum Jülich GmbH grants the User a royalty-free, revocable, non-transferrable, non-exclusive right to use the content for scientific purposes only. 2 The transfer of Atlas content to third parties without the consent of Forschungszentrum Jülich GmbH is prohibited. 3 Should there be any disruptions in the use of the platform or its functionalities, the User shall inform Forschungszentrum Jülich GmbH of this disruption immediately. The same applies if the User obtains information about content published by third parties which obviously violates applicable law or the rights of third parties. 4 The User must list the following papers when citing the atlas: -will be updated upon publication of the manuscript- 5. By downloading the research content, the User assumes full responsibility for the use of the data. He/she is obliged to comply with the provisions of this Terms of Use and good scientific practice. Therefore, the Content User shall indemnify and hold Forschungszentrum Jülich GmbH harmless against claims in connection with their download and/or use.