In-vivo mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Braindoi:10.26165/JUELICH-DATA/HDVEEFJülich DATA2021-12-131Kaulen, Nicolas; Rajkumar, Ravichandran; Régio Brambilla, Claudia; Mauler, Jörg; Ramkiran, Shukti; Orth, Linda; Sbaihat, Hasan; Lang, Markus; Christina, Wyss; Rota Kops, Elena; Scheins, Jürgen; Neumaier, Bernd; Ermert, Johannes; Herzog, Hans; Langen, Karl-Josef; Christoph Lerche; Shah, N.Jon; Veselinović, Tanja; Neuner, Irene, 2021, "In-vivo mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Brain", https://doi.org/10.26165/JUELICH-DATA/HDVEEF, Jülich DATA, V1In-vivo mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Braindoi:10.26165/JUELICH-DATA/HDVEEFKaulen, NicolasRajkumar, RavichandranRégio Brambilla, ClaudiaMauler, JörgRamkiran, ShuktiOrth, LindaSbaihat, HasanLang, MarkusChristina, WyssRota Kops, ElenaScheins, JürgenNeumaier, BerndErmert, JohannesHerzog, HansLangen, Karl-JosefChristoph LercheShah, N.JonVeselinović, TanjaNeuner, IreneJülich DATAIrene NeunerKaulen, Nicolas2021-09-29Medicine, Health and Life SciencesmGluR5, GABAA, PET/MRThis Dataset holds the results of the manuscript entitled "mGluR₅ and GABA_A Receptor Specific Parametric PET Atlas Construction - PET/MR Data Processing Pipeline, Validation and Application". In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BP_ND), and total distribution volume (V_T) based on simultaneously acquired bolus-infusion positron emission tomography (PET) and magnetic resonance imaging (MR) data. The pipeline was applied to [¹¹C]ABP688-PET/MR (13 healthy male non- smokers, 26.6 ± 7.0 years) and [¹¹C]Flumazenil-PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as V_T and BP_ND atlases of mGluR₅ and GABA_A, were generated from these data. An evaluation of PET-to-PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [¹⁵O]H₂O-template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposedpipeline is a viable tool for the construction of standardized PET data distributions. The maps were released to aid further research, by providing healthy in vivo references for the two mentioned neuroreceptor systems which may be used to assess associations with psychiatric and neurologic diseases. In addition, templates of normalized activity concentration distribution were released which were shown to benefit direct PET to PET registration for tracer-specific data.Usage is only permitted according to the accompanying licensing file.CC0 Waiver1 In order to use the Atlas, the User will be required to register and provide the following data ("login data"): a. e-mail-address, b. first and family name and c. a unique password. 2 There is no claim to the use of the services of the Atlas. 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For damages resulting from slightly negligent violations of essential contractual obligations, the liability is limited to typical or foreseeable damages. Forschungszentrum Jülich GmbH is liable for damages resulting from injury to life, body or health, which are based on a willful and negligent breach of duty, as well as for damages according to the Product Liability Act without limitations. 5 Forschungszentrum Jülich GmbH is not liable for damages whose causes are beyond its control, in particular not for damages due to force majeure or for damages caused by Users or third parties in violation of these Terms of Use. https://doi.org/10.1002/hbm.25778Kaulen, N., Rajkumar, R., Régio Brambilla, C., Mauler, J., Ramkiran, S., Orth, L., Sbaihat, H., Lang, M., Wyss, C., Rota Kops, E., Scheins, J., Neumaier, B., Ermert, J., Herzog, H., Langen, K.-J., Lerche, C., Shah, N. J., Veselinović, T., & Neuner, I. (2022). mGluR5 and GABAA receptor-specific parametric PET atlas construction—PET/MR data processing pipeline, validation, and application. Human Brain Mapping, 1– 16. https://doi.org/10.1002/hbm.25778GABA_A_bp_nd_template.nii.gzNon-displaceable binding potential (BP_ND) parametric map of GABA_A receptors for neuroreceptor analysisapplication/x-gzipGABA_A_nac_template.nii.gzNormalized activity concentration template for tracer specific ([11C]Flumazenil) PET to PET registrationapplication/x-gzipGABA_A_vt_template.nii.gzTotal volume of distribution (V_T) parametric map of GABA_A receptors for neuroreceptor analysisapplication/x-gzipmGluR5_bp_nd_template.nii.gzNon-displaceable binding potential (BP_ND) parametric map of mGluR5 receptors for neuroreceptor analysisapplication/x-gzipmGluR5_nac_template.nii.gzNormalized activity concentration template for tracer specific ([11C]ABP688) PET to PET registrationapplication/x-gzipmGluR5_vt_template.nii.gzTotal volume of distribution (V_T) parametric map of mGluR5 receptors for neuroreceptor analysisapplication/x-gzipPrivacy_Policy_mGluR5_and_GABAA_Receptor_Specific_Parametric_PET_Atlas.docxPrivacy Policy of mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Brainapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentTerms_of_Use_mGluR5_and_GABAA_Receptor_Specific_Parametric_PET_Atlas.docxIn-vivo mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Brain – Terms of Useapplication/vnd.openxmlformats-officedocument.wordprocessingml.document