In-vivo mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Brain

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Kaulen, Nicolas; Rajkumar, Ravichandran; Régio Brambilla, Claudia; Mauler, Jörg; Ramkiran, Shukti; Orth, Linda; Sbaihat, Hasan; Lang, Markus; Christina, Wyss; Rota Kops, Elena; Scheins, Jürgen; Neumaier, Bernd; Ermert, Johannes; Herzog, Hans; Langen, Karl-Josef; Christoph Lerche; Shah, N.Jon; Veselinović, Tanja; Neuner, Irene, 2021, "In-vivo mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Brain", https://doi.org/10.26165/JUELICH-DATA/HDVEEF, Jülich DATA, V1

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Description	This Dataset holds the results of the manuscript entitled "mGluR ₅ and GABA _A Receptor Specific Parametric PET Atlas Construction - PET/MR Data Processing Pipeline, Validation and Application". In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BP _ND), and total distribution volume (V _T) based on simultaneously acquired bolus-infusion positron emission tomography (PET) and magnetic resonance imaging (MR) data. The pipeline was applied to [ ¹¹C]ABP688-PET/MR (13 healthy male non- smokers, 26.6 ± 7.0 years) and [ ¹¹C]Flumazenil-PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as V _T and BP _ND atlases of mGluR ₅ and GABA _A, were generated from these data. An evaluation of PET-to-PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [ ¹⁵O]H ₂O-template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposedpipeline is a viable tool for the construction of standardized PET data distributions. The maps were released to aid further research, by providing healthy in vivo references for the two mentioned neuroreceptor systems which may be used to assess associations with psychiatric and neurologic diseases. In addition, templates of normalized activity concentration distribution were released which were shown to benefit direct PET to PET registration for tracer-specific data. (2021-09-29)
Subject	Medicine, Health and Life Sciences
Keyword	mGluR5, GABAA, PET/MR
Related Publication	Kaulen, N., Rajkumar, R., Régio Brambilla, C., Mauler, J., Ramkiran, S., Orth, L., Sbaihat, H., Lang, M., Wyss, C., Rota Kops, E., Scheins, J., Neumaier, B., Ermert, J., Herzog, H., Langen, K.-J., Lerche, C., Shah, N. J., Veselinović, T., & Neuner, I. (2022). mGluR5 and GABAA receptor-specific parametric PET atlas construction—PET/MR data processing pipeline, validation, and application. Human Brain Mapping, 1– 16. https://doi.org/10.1002/hbm.25778 doi: https://doi.org/10.1002/hbm.25778
Notes	Usage is only permitted according to the accompanying licensing file.
Institute	INM-4

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	GABA_A_bp_nd_template.nii.gz GABA_A/ Gzip Archive - 15.1 MB - Dec 13, 2021 - 2 Downloads SHA-256: 9aaa35978d8e888c21e988f52ceeaff1e65ac0297664d71c3827a76e37122023 Non-displaceable binding potential (BP_ND) parametric map of GABA_A receptors for neuroreceptor analysis	Request Access
	GABA_A_nac_template.nii.gz GABA_A/ Gzip Archive - 61.2 MB - Dec 13, 2021 - 2 Downloads SHA-256: 6e9f2e501bd018e8e53c68d5943f68b5da62f798b97596bd5299cfbec84e1512 Normalized activity concentration template for tracer specific ([11C]Flumazenil) PET to PET registration	Request Access
	GABA_A_vt_template.nii.gz GABA_A/ Gzip Archive - 14.9 MB - Dec 13, 2021 - 2 Downloads SHA-256: 8717b4b048838ed3ba7aaf81e4015ff417a0a995f3f0a84e67a9c577485debb9 Total volume of distribution (V_T) parametric map of GABA_A receptors for neuroreceptor analysis	Request Access
	mGluR5_bp_nd_template.nii.gz mGluR5/ Gzip Archive - 14.9 MB - Dec 13, 2021 - 3 Downloads SHA-256: e948460b7de92eb736b703f5d2ab3df0348ec3e9462b4ed1bed18f07ca461d02 Non-displaceable binding potential (BP_ND) parametric map of mGluR5 receptors for neuroreceptor analysis	Request Access
	mGluR5_nac_template.nii.gz mGluR5/ Gzip Archive - 61.3 MB - Dec 13, 2021 - 3 Downloads SHA-256: f8a612bc8a1a4320536789174859967f18b3a34641546bed7382261f17e46e79 Normalized activity concentration template for tracer specific ([11C]ABP688) PET to PET registration	Request Access
	mGluR5_vt_template.nii.gz mGluR5/ Gzip Archive - 14.8 MB - Dec 13, 2021 - 3 Downloads SHA-256: ad1531dab7d5a467e6cbc24fda311ba40836c897b1e9d48bb7d3a2737ec62da7 Total volume of distribution (V_T) parametric map of mGluR5 receptors for neuroreceptor analysis	Request Access
	Privacy_Policy_mGluR5_and_GABAA_Receptor_Specific_Parametric_PET_Atlas.docx MS Word - 29.1 KB - Dec 13, 2021 - 4 Downloads SHA-256: c6c16cf1245c2a425cad2ad8a3ebab4ad9ab63b3d07b53e7ab9142a01f6148df Privacy Policy of mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Brain	Download
	Terms_of_Use_mGluR5_and_GABAA_Receptor_Specific_Parametric_PET_Atlas.docx MS Word - 33.0 KB - Dec 13, 2021 - 6 Downloads SHA-256: 937890a6ee94b8a60284b349227088ee8f83fca798f00ca2fd29d93b0de0d2b1 In-vivo mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Brain – Terms of Use	Download

Citation Metadata

Dataset Persistent ID	doi:10.26165/JUELICH-DATA/HDVEEF
Publication Date	2021-12-13
Title	In-vivo mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Brain
Author	Kaulen, Nicolas (Forschungszentrum Jülich GmbH) - ORCID: 0000-0002-0562-0490 Rajkumar, Ravichandran (Forschungszentrum Jülich GmbH) - ORCID: 0000-0001-5875-5316 Régio Brambilla, Claudia (Forschungszentrum Jülich GmbH) Mauler, Jörg (Forschungszentrum Jülich GmbH) Ramkiran, Shukti (Forschungszentrum Jülich GmbH) Orth, Linda (Forschungszentrum Jülich GmbH) Sbaihat, Hasan (Forschungszentrum Jülich GmbH) Lang, Markus (Forschungszentrum Jülich GmbH) Christina, Wyss (Department for Psychiatry, Psychotherapy and Psychosomatics Social Psychiatry, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland) Rota Kops, Elena (Forschungszentrum Jülich GmbH) Scheins, Jürgen (Forschungszentrum Jülich GmbH) Neumaier, Bernd (Forschungszentrum Jülich GmbH) Ermert, Johannes (Forschungszentrum Jülich GmbH) Herzog, Hans (Forschungszentrum Jülich GmbH) Langen, Karl-Josef (Forschungszentrum Jülich GmbH) Christoph Lerche (Forschungszentrum Jülich GmbH) Shah, N.Jon (Forschungszentrum Jülich GmbH) Veselinović, Tanja (Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, 52062 Aachen, Germany) Neuner, Irene (Forschungszentrum Jülich GmbH)
Contact	Use email button above to contact. Irene Neuner (Forschungszentrum Jülich GmbH)
Description	This Dataset holds the results of the manuscript entitled "mGluR ₅ and GABA _A Receptor Specific Parametric PET Atlas Construction - PET/MR Data Processing Pipeline, Validation and Application". In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BP _ND), and total distribution volume (V _T) based on simultaneously acquired bolus-infusion positron emission tomography (PET) and magnetic resonance imaging (MR) data. The pipeline was applied to [ ¹¹C]ABP688-PET/MR (13 healthy male non- smokers, 26.6 ± 7.0 years) and [ ¹¹C]Flumazenil-PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as V _T and BP _ND atlases of mGluR ₅ and GABA _A, were generated from these data. An evaluation of PET-to-PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [ ¹⁵O]H ₂O-template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposedpipeline is a viable tool for the construction of standardized PET data distributions. The maps were released to aid further research, by providing healthy in vivo references for the two mentioned neuroreceptor systems which may be used to assess associations with psychiatric and neurologic diseases. In addition, templates of normalized activity concentration distribution were released which were shown to benefit direct PET to PET registration for tracer-specific data. (2021-09-29)
Subject	Medicine, Health and Life Sciences
Keyword	mGluR5, GABAA, PET/MR
Related Publication	Kaulen, N., Rajkumar, R., Régio Brambilla, C., Mauler, J., Ramkiran, S., Orth, L., Sbaihat, H., Lang, M., Wyss, C., Rota Kops, E., Scheins, J., Neumaier, B., Ermert, J., Herzog, H., Langen, K.-J., Lerche, C., Shah, N. J., Veselinović, T., & Neuner, I. (2022). mGluR5 and GABAA receptor-specific parametric PET atlas construction—PET/MR data processing pipeline, validation, and application. Human Brain Mapping, 1– 16. https://doi.org/10.1002/hbm.25778 doi: https://doi.org/10.1002/hbm.25778 https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.25778
Notes	Usage is only permitted according to the accompanying licensing file.
Depositor	Kaulen, Nicolas
Deposit Date	2021-09-29

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PoF IV topic	Not covered by a PoF IV topic (POF4-899)

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